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KMID : 1195620130060040243
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Clinical and Experimental Otorhinolaryngology
2013 Volume.6 No. 4 p.243 ~ p.248
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Relationships between Tumor Volume and Lymphatic Metastasis and Prognosis in Early Oral Tongue Cancer
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Joo Young-Hoon
Hwang Se-Hwan
Sun Dong-Il
Cho Kwang-Jae
Park Jun-Ook
Kim Min-Sik
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Abstract
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Objectives: Although T stage is an important prognostic tool for oral tongue cancer, it fails to define the depth of invasion and true three-dimensional volume of primary tumors. The purpose of this paper is to determine the relations between tumor volume and lymph node metastasis and survival in early oral tongue cancer.
Methods: Forty-seven patients with T1-2 tongue cancer were included. Tumor volumes were measured by the computerized segmentation of T2-weighted magnetic resonance imaging.
Results: The overall average tumor volume was 27.7 cm3 (range, 1.4 to 60.1 cm3). A significant positive correlation was found between tumor volume and pathological T stage, depth of invasion, and cervical lymph node metastasis (P<0.001, P<0.001, and P=0.002, respectively). When the tumor volume exceeded 20 cm3, the cervical metastasis rate increased to 69.2%. The overall 5-year disease specific survival rate was 80%. There was a statistically significant association between large tumor volume (≥20 cm3) and the 5-year disease-specific survival (P=0.046).
Conclusion: Tumor volume larger than 20 cm3 was associated with greater risk cervical lymph node metastasis and poor 5-year disease-specific survival rate in early oral tongue cancer patients
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KEYWORD
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Tongue neoplasms, Tumor burden, Lymphatic metastasis, Computer-assisted image processing, Magnetic resonance imaging
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